Description
BPC-157 Research Peptide | 10mg
BPC-157 (Body Protection Compound-157) is a synthetic pentadecapeptide derived from a partial sequence of a ~40 kDa protein first isolated from human gastric juice. This 15-amino acid fragment has been extensively characterized in peer-reviewed in-vitro and animal model research spanning three decades.
Structural Characteristics
BPC-157 is a linear peptide lacking disulfide bonds. Its remarkable stability derives primarily from four proline residues at positions 3, 4, 5, and 8, including a distinctive triple-proline motif (PPP). This proline-rich sequence introduces conformational rigidity that strongly resists proteolytic degradation by trypsin, chymotrypsin, and catheptic proteases. BPC-157 remains stable in human gastric juice for more than 24 hours—an exceptionally long duration compared to most peptides.
Characterized Signaling Pathways
Published research has identified multiple cellular signaling interactions:
Nitric Oxide System: Research by Hsieh et al. (Scientific Reports, 2020) demonstrated that BPC-157 induces phosphorylation of eNOS at Ser1177 through the Src-Caveolin-1-eNOS signaling cascade, reducing inhibitory Cav-1-eNOS complex formation and enabling NO production.
VEGFR2 Pathway: Studies show BPC-157 upregulates VEGFR2 mRNA and protein expression in vascular endothelial cells, promoting receptor internalization and activating downstream VEGFR2-Akt-eNOS signaling (Hsieh et al., Journal of Molecular Medicine, 2017).
Growth Hormone Receptor: cDNA microarray analysis identified GHR as abundantly upregulated following BPC-157 treatment, with dose-dependent increases reaching up to 7-fold elevation in both mRNA and protein levels (Chang et al., Molecules, 2014).
FAK-Paxillin Cascade: Western blot analysis confirmed dose-dependent increases in phosphorylation of both FAK and paxillin, correlating with enhanced fibroblast migration and F-actin formation (Chang et al., Journal of Applied Physiology, 2011).
Research Applications
BPC-157 has been utilized as a molecular probe in controlled experimental systems examining:
– Gastrointestinal mucosal integrity models
– Connective tissue and fibroblast behavior
– Tendon and ligament biology
– Angiogenic signaling pathways
– Extracellular matrix dynamics
– Oxidative stress modulation
– Cellular migration mechanisms
